Dr. V. Padma Anuradha 01 01 Ferrofluids colloidal suspensions of magnetic nanoparticles typically magnetite FeO with diameters ranging from 10 to 100 nanometers represent a transformative platform for targeted drug delivery in nanotechnology These biocompatible magnetic nanomaterials operate on the principle of magnetism enabling precise spatial control over therapeutic agents through external magnetic field manipulation This comprehensive review examines the fundamental principles formulation strategies mechanistic pathways and diverse biomedical applications of ferrofluidbased drug delivery systems The unique superparamagnetic properties of ferrofluids arising from their nanoscale magnetic domains allow for noninvasive targeting of therapeutic agents to specific anatomical sites while minimizing systemic toxicity Ferrofluids have been extensively investigated for applications including cell separation immunoassay gene delivery minimally invasive surgery magnetic resonance imaging contrast enhancement and hyperthermiabased cancer therapy The mechanism of magnetic targeted drug delivery involves encapsulation or conjugation of therapeutic agents with ferrofluid carriers followed by intravenous administration and magnetic fieldguided accumulation at target sites Despite significant advantages including reduced reticuloendothelial system clearance controlled drug release profiles and enhanced sitespecificity ferrofluidbased systems face limitations including inability to target deepseated organs technical complexity and requirements for specialized equipment This review synthesizes current knowledge on ferrofluidbased drug delivery systems highlighting recent advancements and identifying future research directions for optimizing these promising nanocarriers in clinical applications Copyright (c) Journal of Science Engineering Technology and Management Science. All rights reserved 2026