Article

An Innovative Use of Interweaving in an Extended Playfair Cypher on DNA-Encoded Data

Author : P. Vijay and K. Srinivasa Rao

DOI : http://doi.org/10.63590/jsetms.2025.v02.i06.pp16-20

The advanced field of cryptography makes extensive use of bioinformatics together with other domains as one of its applications. The presented cypher operates by converting messages of all types—including texts and audio files and images—into sequences consisting of single-stranded DNA. A matrix of randomly generated 8x8 codon squares derived from the security key serves to encrypt series of triple codon sequences. The DNA encoding process creates such a significant difficulty that attackers cannot perform frequency analysis despite preserving the original encryption/decryption rules of traditional 5x5 Playfair. An interweaving operation should be added as a step to encrypt the sequence because it enhances unpredictability. Workers who used this approach gained multiple benefits against Playfair cypher modifications because their system encrypted all digital content types without text processing and integrated well for DNA steganography purposes. The proposed technique shows resistant behavior against cypher attacks because the original message and cipher-data bear minimal correlation between them.


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