Detecting side-effects arising from adverse drug–drug interactions (DDIs) has become a crucial focus in modern pharmacovigilance, driven by the widespread use of polypharmacy and the growing need for automated, data-driven safety monitoring. Existing research demonstrates significant progress in DDI prediction, adverse drug reaction (ADR) detection, and pharmacological feature modeling through methods such as label propagation, multi-dimensional feature fusion, graph neural networks (GNNs), and deep neural architectures [1–14]. Recent studies emphasize the increasing reliance on real-world evidence, spontaneous reporting systems, electronic health records, and curated datasets such as TWOSIDES, OFFSIDES, DrugBank, and FAERS to improve the reliability of interaction-based ADR identification [4–7, 15–20]. Building upon these advancements, this work proposes an enhanced DDIbased side-effect detection framework that integrates molecular representation learning, spatiostructural drug-feature fusion, and signal-detection analysis to accurately identify harmful interaction-induced reactions. Leveraging insights from network-based inference, statistical disproportionality methods, and interpretable machine learning models, the system aims to improve prediction accuracy while reducing false positive signals. The study contributes a unified analysis of traditional pharmacovigilance techniques and contemporary AI-driven approaches, highlighting their strengths, limitations, and applicability to real-world clinical settings. The proposed model aligns with emerging trends in intelligent drug-safety surveillance and offers a scalable, explainable solution suitable for large-scale healthcare environments.
Keywords : Drug–drug interactions, adverse drug reactions, pharmacovigilance, deep learning, graph neural networks, molecular feature fusion, TWOSIDES dataset, OFFSIDES dataset, signal detection, disproportionality analysis, electronic health records, machine learning, drug safety monitoring, sideeffect prediction, healthcare analytics.
Author : Mr. N.Chandira Prakash, Dyagari Sathvika, Rachala Charitha, Kallem Supriya, Peram Bharghav Reddy
Title : MONITORING AND PREDICTION OF SIDE EFFECTS FROM POLYPHARMACY-INDUCED INTERACTIONS
Volume/Issue : 2025;02(11)
Page No : 83-91